Differential
stimulation of neutrophil functions by Pyritinol.
Elferink JG, de Koster BM.
Dept, of Medical Biochemistry,
Univ of Leiden, The Netherlands.
Int J Immunopharmacol 1993 Jul;15(5):641-6
ABSTRACT
The drug
pyritinol strongly
stimulated in vitro migration by rabbit peritoneal neutrophils. The
stimulating effect appeared to be chemotactic rather than chemokinetic. Though
the drug did not induce exocytosis by itself, it stimulated
fMet-Leu-Phe-induced exocytosis. The effect on exocytosis induced by other
activators was not statistically significant. No stimulating effect of
pyritinol on superoxide production was observed, either in the absence or
in the presence of activators. For a maximal stimulating effect on migration
and exocytosis the presence of extracellular Ca2+ was required. Pyritinol
caused an increase of cGMP level in neutrophils. The hypothesis is presented
that the differential activation of neutrophil functions by
pyritinol is
mediated by cGMP, and that cGMP has a differential importance for the
neutrophil functions studied.
